ANA 17 profile Blot with Myositis Profile
Do not miss Myositis Profile while screening for ANA
-
Cost effective differential diagnosis
-
17 important ANA screening antigens on the same strip including Myositis antigens ( Ku & Mi2) and PBC ( AMA- M2).
-
Most pure ds DNA coated on the strip to give specific results
-
Clear bands on the strip without any background
-
No calibrators needed
-
No controls needed ( already in the strip)
-
Minimal lab equipment needed
Immunoblot for the qualitative detection of IgG antibodies against:
dsDNA, nucleosomes, histones, SmD1, PCNA, P0, SS-A/Ro60kD, SS-A/Ro52kD, SS-B/La, CENP -B, Scl-70, U1 snRNP, AMA M2, Jo-1, Pm-Scl, Ku and Mi-2 in human serum or plasma.
24 tests/kit
Conjugate: anti-human IgG HRP
Color-coded (orange) test strips with cut-off and positive control
Easy to use software for result interpretation
For easy interpretation of the AESKUBLOTS, AESKU. DIAGNOSTICS provides the dedicated evaluation software AESKUSCAN.
Fill in the details to set ANA 17 blot in your lab
Mi-2 detection for specific PM/DM diagnosis :
Significance of Ku detection:
With various roles in body like DNA- binding, barrier to transcriptional activation, regulation of developmental processes and skin development and repair of basal epidermis, Mi-2 is considered to be a very important antigen for specific PM/DM diagnosis.
-
Mi-2 is "Myositis-Specific Antibody"(MSA) (It is extremely rare to find these antibodies in patients without myositis, even if they have another muscle or autoimmune disease.)
-
MSA are found almost exclusively in patients with DM/PM and associated overlap syndromes
-
This antibody is associated with Dermatomyositis without other associated connective tissue disorders.
-
15-20 % Dermatomyositis with a high diagnostic specificity. 95 % of patients with Mi-2 antibodies suffer from dermatomyositis.
-
15-20 % Dermatomyositis with a high diagnostic specificity. 95 % of patients with Mi-2 antibodies suffer from dermatomyositis.
As postulated, Ku antibodies could be found in 55% overlap PM/Systemic sclerosis patients, it is considered to be very important antigen. The anti-Ku antibodies are reported in various connective tissue diseases and the Ku complex can be responsible for a very strong autoimmune answer in autoimmune diseases.
Ku antibodies occurrence:
-
5-25 % :- Polymyositis and scleroderma overlap-syndrome .
-
1-7 % :- Myositis .
-
20 % :- Primary pulmonary hypertension
-
5-10 % :- SLE .
-
20 % :- Primary Sjögren’s syndrome
Related Products